General Information

  • ID:  hor005785
  • Uniprot ID:  P11006
  • Protein name:  Magainin-1
  • Gene name:  magainins
  • Organism:  Xenopus laevis (African clawed frog)
  • Family:  Gastrin/cholecystokinin family, Magainin subfamily
  • Source:  animal
  • Expression:  Synthesized in the stomach and stored in a novel granular multinucleated cell in the gastric mucosa. It is stored as active, processed peptides in large granules within the granular gland secretions of the skin.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0002376 immune system process; GO:0006952 defense response; GO:0031640 killing of cells of another organism; GO:0042742 defense response to bacterium; GO:0045087 innate immune response; GO:0050688 regulation of defense response to virus; GO:0050832 defense response to fungus
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GIGKFLHSAGKFGKAFVGEIMKS
  • Length:  23(37-59)
  • Propeptide:  MFKGLFICSLIAVICANALPQPEASADEDMDEREVRGIGKFLHSAGKFGKAFVGEIMKSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDLDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAFADEDFDEREVRGIGKFLHSAKKFGKAFVGEIMNSKRDAEAVGPEAF
  • Signal peptide:  MFKGLFICSLIAVICANA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Rapidly inactivates channel catfish herpesvirus (ED(50)=48 uM) over a wide temperature range (PubMed:15193922). Magainins are me
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P11006-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor005785_AF2.pdbhor005785_ESM.pdb

Physical Information

Mass: 280247 Formula: C112H177N29O28S
Absent amino acids: CDNPQRTWY Common amino acids: G
pI: 10.8 Basic residues: 5
Polar residues: 7 Hydrophobic residues: 9
Hydrophobicity: 21.74 Boman Index: -206
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 72.17
Instability Index: -379.57 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2833514
  • Title:  The cDNA sequence coding for prepro-PGS (prepro-magainins) and aspects of the processing of this prepro-polypeptide.
  • PubMed ID:  3299384
  • Title:  Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequenc
  • PubMed ID:  1717472
  • Title:  
  • PubMed ID:  15193922
  • Title:  
  • PubMed ID:  8298457
  • Title: